Skin boosters are advanced aesthetic treatments designed to improve your skin's overall quality and appearance. These treatments enhance skin hydration, texture, and elasticity, providing a more youthful and radiant look. By delivering essential substances such as hyaluronic acid or DNA fragments into the skin, skin boosters work beneath the surface to address issues like dryness, fine lines, and loss of firmness. The primary goal is rejuvenation by stimulating natural processes that support healthier, more resilient skin. This approach offers a holistic solution for achieving a smoother and more vibrant complexion, making skin boosters appealing for those seeking to refresh and revitalise their skin.

Profhilo is an advanced regenerative skin treatment known for its ability to act as a powerful skin bioremodeller thanks to its high concentration of hyaluronic acid (HA). Each 2ml prefilled syringe of Profhilo contains 64mg of HA, a concentration significantly higher than what is typically found in most dermal fillers. Its formulation is unique in that it combines both high- and low-molecular-weight HA, which are heat-bonded rather than chemically cross-linked. This method of bonding ensures stability and a prolonged presence in the tissue, enhancing Profhilo’s ability to rejuvenate the skin by stimulating the production of collagen and elastin.

Unlike traditional dermal fillers, which often contain BDDE (1,4-Butanediol diglycidyl ether) to cross-link and thicken the product, Profhilo is not cross-linked and so free from BDDE. This absence gives Profhilo a thinner consistency, allowing it to spread more easily and evenly across the skin. As a result, it effectively distributes hydration throughout the treated area, improving skin texture and elasticity.

Profhilo works by attracting and retaining moisture in the deeper layers of the skin, enhancing hydration and further improving skin texture and elasticity. The treatment is administered by injecting small amounts of this biocompatible gel using fine needles. Specific areas such as the face, neck, and décolletage are targeted to address issues like skin laxity, tiredness, and dehydration.

Particularly effective for rejuvenating skin that has lost its firmness and tone, Profhilo is ideal for those looking to improve overall skin quality. However, it is not designed to treat deep lines and scars or add volume since these concerns are better addressed with traditional dermal fillers. A topical anaesthetic cream may be applied before the procedure to minimise discomfort.

The treatment typically involves two sessions spaced four weeks apart. For optimal results, additional courses are recommended every 3 to 6 months. Some patients may prefer maintenance sessions every 3 months, while others may choose to extend the interval based on their individual response and skin type. Results generally become noticeable within 4 to 6 weeks and can last around 6 months, though this can vary. Multiple sessions may be needed to achieve and maintain the desired outcomes, with individual results varying from person to person.

Polynucleotides are an advanced regenerative treatment designed to enhance skin quality, texture, and hydration. This treatment involves the use of DNA fragments derived from natural sources, typically extracted from the regenerative cells (sperm and testicle) of salmon or trout. These fragments stimulate cellular repair and regeneration, improve tissue elasticity, and provide deep hydration.

Administered through small intradermal injections with very fine needles, polynucleotides are ideal for rejuvenating skin on the face, neck, décolletage, and other areas affected by aging. The treatment effectively addresses issues such as tired, aged, and lax skin, dehydration, fine lines, superficial wrinkles, and environmental damage. Polynucleotides activate A2A receptors, which boost fibroblast activity and promote collagen and elastin production. This leads to enhanced tissue regeneration, increased hydration, improved skin elasticity, tone, firmness, anti-inflammatory benefits and better pigmentation regulation.

Typically, achieving optimal results requires 2-3 sessions spaced 2-3 weeks apart, with around 3 sessions generally recommended for noticeable improvements. It takes about 3 months for the full effects to become apparent as the skin undergoes gradual cellular changes. To sustain the results, a maintenance treatment is advised every 6-12 months. The treatment is administered in small quantities using fine needles or cannulas (thin, flexible tubes) to ensure precise and effective delivery.

Polynucleotides' history and scientific development are deeply rooted in the broader understanding of DNA and RNA, which has significantly evolved over the last century.

Discovery and Early Research (19th to 20th Century)

Polynucleotides, as chains of nucleotides, are integral components of DNA and RNA. The foundational discovery of these molecules dates back to the 19th century.

• 1869: Swiss chemist Friedrich Miescher first identified "nuclein" (now known as nucleic acid) in the nuclei of white blood cells. This was the earliest discovery of the substance that we now understand as DNA, composed of polynucleotide chains.

• 1953: James Watson and Francis Crick famously elucidated the double-helix structure of DNA, significantly advancing our understanding of nucleic acids. Their discovery confirmed that DNA was composed of two intertwined polynucleotide strands.

Early Uses in Medicine (Mid 20th Century)

Before polynucleotides were applied in aesthetics, their biological properties were explored in various medical fields, particularly in regenerative medicine and wound healing.

• 1960s-1970s: Researchers began investigating the potential of DNA and its components for medical applications. During this period, polynucleotides were studied for their role in tissue repair and regeneration. Initial experiments focused on their ability to enhance cellular activity and accelerate the healing process in damaged tissues.

• 1980s: Polynucleotide research gained momentum in the context of wound healing. Studies demonstrated that DNA fragments could stimulate cell proliferation and tissue regeneration, which led to their use in treating difficult-to-heal wounds, such as ulcers and burn injuries.

Transition to Aesthetic Medicine (Late 20th Century to Early 21st Century)

The transition of polynucleotides into the field of aesthetic medicine is relatively recent compared to their earlier medical uses.

• 1990s: The cosmetic potential of DNA and polynucleotides began to be explored, particularly in Asia and Europe. Researchers started focusing on the skin’s regenerative properties and how polynucleotides could be used to rejuvenate aged or damaged skin. Salmon DNA, in particular, was identified as a rich source of polynucleotides due to its compatibility with human skin and its ability to promote cellular repair.

• Early 2000s: Aesthetic clinics in South Korea and Italy were among the first to popularise the use of salmon DNA in skincare treatments. The introduction of injectable polynucleotide treatments provided a new approach to anti-aging therapies, focusing on deep skin regeneration rather than surface-level improvements.

Modern Uses and Ongoing Research

Today, polynucleotides are widely recognised for their effectiveness in skin rejuvenation, thanks to their ability to repair and regenerate skin at the cellular level.

• 2010s-Present: The use of polynucleotides in aesthetic medicine became more widespread, with clinical studies supporting their efficacy in improving skin texture, hydration, and elasticity. Their application has expanded beyond facial rejuvenation to include treatments for the neck, décolletage, and hands. Moreover, polynucleotides are being researched for their potential in treating more severe skin conditions, such as acne scars and photoaged skin.

• Future Directions: Current research continues to explore the broader potential of polynucleotides in regenerative medicine. This includes investigating their use in orthopaedics for cartilage repair, in ophthalmology for treating eye injuries, and in other areas where tissue regeneration is critical.

Polynucleotides have transitioned from their initial discovery as a fundamental component of DNA to a versatile tool in medicine and aesthetics. Their journey from wound healing applications to modern skin rejuvenation therapies reflects the growing understanding of their regenerative capabilities.

Polynucleotides and Profhilo are both advanced aesthetic treatments used for skin rejuvenation, but they differ significantly in their composition, mechanisms, and ideal applications.

Polynucleotides are composed of nucleotides, the building blocks of DNA, often derived from natural sources like salmon DNA. They work by stimulating deep cellular renewal and repair, enhancing skin hydration from within, and boosting fibroblast activity to increase collagen and elastin production. This process improves skin texture and elasticity and helps reduce fine lines, wrinkles, and scars. Polynucleotides are particularly effective for comprehensive skin healing and repair, making them ideal for treating damaged or scarred skin and for mature skin needing deeper regeneration and long-lasting results.

Profhilo, in contrast, is a skin bioremodelling injectable with a high concentration of non-cross-linked hyaluronic acid. This unique formulation allows Profhilo to spread effortlessly through the skin, providing immediate hydration and stimulating collagen and elastin production. It enhances overall skin tone, texture, and elasticity while delivering a noticeable firming and lifting effect. Profhilo's ability to provide immediate hydration and stimulate collagen production makes it especially appealing for individuals seeking a quick improvement in skin quality.

While polynucleotides stimulate the skin to renew from within by activating cellular processes and enhancing deeper layers of the skin, Profhilo provides immediate hydration through the direct delivery of hyaluronic acid. This difference in approach means that polynucleotides may require more time to show results, with improvements becoming noticeable over approximately 3 months and lasting up to 6 months with ongoing maintenance treatments every 6-12 months. In contrast, Profhilo typically shows visible results within 4-6 weeks after two initial treatments spaced a month apart, with maintenance sessions recommended every 3-6 months.

Polynucleotides offer targeted repair and deeper cellular rejuvenation for individuals with specific skin damage or severe aging. Profhilo is ideal for those seeking overall skin quality enhancement, hydration, dewiness, and a subtle lifting effect. Both treatments generally have minimal side effects, such as slight redness, swelling, or bruising at the injection sites, making them safe and effective options for improving skin quality.

Polynucleotides and Profhilo are generally considered safe when administered by a trained and experienced professional. However, as with any medical or cosmetic procedure, they come with potential risks and side effects.

Polynucleotides, composed of DNA fragments often derived from natural sources like salmon, are usually well-tolerated. Common side effects include mild redness, swelling, and bruising at the injection sites, which typically resolve within a few days. Rarely, patients might experience allergic reactions or infections. It's essential to follow aftercare instructions and report any unusual symptoms. Polynucleotides may not be suitable for individuals with certain medical conditions or those who are pregnant or breastfeeding. A thorough medical evaluation is necessary to ensure the treatment is appropriate.

Profhilo, a skin bioremodelling injectable containing high concentrations of non-cross-linked hyaluronic acid, also has a good safety profile when administered by an experienced clinician. The most common side effects are temporary redness, swelling, and bruising at the injection sites, which generally subside quickly. Though rare, there is a potential for allergic reactions or infections. As with polynucleotides, adhering to aftercare guidelines, such as avoiding excessive sun exposure and strenuous activities, is important for minimising risks. Profhilo is not recommended for pregnant or breastfeeding women, and a detailed assessment of health conditions is necessary before treatment.

Overall, both treatments are considered safe. During the consultation, we will assess your suitability for the procedure and provide personalised advice to help ensure the best possible outcomes while minimising potential risks.

The pain experienced during skin booster treatments like Profhilo and polynucleotides is generally minimal, but it can vary depending on individual sensitivity and the area being treated.

Profhilo: The procedure typically uses fine needles, which helps to minimise discomfort. Most patients find the procedure tolerable without the need for topical anaesthetic. However, a topical numbing cream may be applied beforehand to reduce pain. While some patients report a slight stinging or pinching sensation during the injections, it is usually brief and manageable.

Polynucleotides: Similar to Profhilo, polynucleotides are administered via fine needles. The sensation of the injections is generally mild, though some patients might experience a slight pinch or pressure. A topical anaesthetic cream may be applied before the procedure to enhance comfort. The discomfort is usually well-tolerated, and any sensation of pain is typically brief.

Overall, both treatments are designed to be minimally invasive and cause only mild discomfort. If you have concerns about pain or discomfort, discussing these before the procedure can help ensure appropriate measures are taken to make the experience as comfortable as possible.